抗原
T细胞受体
生物
受体
T细胞
人口
蛋白酵素
细胞生物学
分子生物学
生物化学
化学
免疫系统
免疫学
酶
人口学
社会学
作者
Yoshimasa Tanaka,Susumu Sano,Edward Nieves,Gennaro De Libero,Daniela Santoro Rosa,Robert L. Modlin,Michael B. Brenner,Barry R. Bloom,Craig T. Morita
标识
DOI:10.1073/pnas.91.17.8175
摘要
gamma delta T cells respond to a variety of microbial pathogens and transformed cells. Their limited receptor repertoire and activation by mycobacterial antigens resistant to proteases suggest that they may recognize nonpeptide antigens. We have tested a variety of nonpeptide molecules for stimulation of human gamma delta T cells. Synthetic alkyl phosphates, particularly monoethyl phosphate (MEP), selectively activated gamma delta T cells and stimulated their proliferation in vitro. All gamma delta T cells stimulated by MEP expressed V gamma 2/V delta 2 receptors. The purified natural ligand of mycobacteria is chemically similar to, though distinct from, MEP and contains a phosphate residue that is critical for biological activity. Recognition and expansion of a specific T-cell receptor-bearing population to non-peptide ligands is unprecedented among T cells. We suggest that MEP mimics small natural ligands capable of expanding one subset of gamma delta T cells and that this recognition of nonpeptide antigens may play an important role in human immunity to pathogens.
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