Differential Interferometric Synthetic Aperture Radar (D-InSAR) is a new technology which is capable of detecting the tiny ground deformation and extracting Digital Elevation Model (DEM). This paper introduces the basic principle of D-InSAR. Using of two pass model and SRTM DEM, acquired Kunlun Mountains region surface deformation of Ms8.1 in 2001. The result provides an important reference for Qinghai-Tibet Railway Disaster Prevention.