Impact of Early Enteral Nutrition on In-Hospital Mortality in Patients with Hypertensive Intracerebral Hemorrhage

Objective : We conducted this study to evaluate the clinical impact of early enteral nutrition (EN) on in-hospital mortality and outcome in patients with critical hypertensive intracerebral hemorrhage (ICH).Methods : We retrospectively analyzed 123 ICH patients with Glasgow Coma Scale (GCS) score of 3-12.We divided the subjects into two groups : early EN group (< 48 hours, n = 89) and delayed EN group (≥ 48 hours, n = 34).Body weight, total intake and output, serum albumin, Creactive protein, infectious complications, morbidity at discharge and in-hospital mortality were compared with statistical analysis.Results : The incidence of nosocomial pneumonia and length of intensive care unit stay were significantly lower in the early EN group than in the delayed EN group (p < 0.05).In-hospital mortality was less in the early EN group than in the delayed EN group (10.1% vs. 35.3%,respectively; p = 0.001).By multivariate analysis, early EN [odds ratio (OR) 0.229, 95% CI : 0.066-0.793],nosocomial pneumonia (OR = 5.381, 95% CI : 1.621-17.865)and initial GCS score (OR = 1.482 95% CI : 1.160-1.893)were independent predictors of in-hospital mortality in patients with critical hypertensive ICH. Conclusion :These findings indicate that early EN is an important predictor of outcome in patients with critical hypertensive ICH.