钌
席夫碱
转移加氢
催化作用
配体(生物化学)
化学
晶体结构
手性配体
药物化学
高分子化学
对映选择合成
立体化学
结晶学
有机化学
受体
生物化学
作者
Hoi‐Lun Kwong,Wing Sze Lee,Tat Shing Lai,Wing Tak Wong
标识
DOI:10.1016/s1387-7003(99)00012-x
摘要
A ruthenium catalyst, generated in situ by heating the chiral P,N,O Schiff base ligand L (L = (S)-Ph2PC6H4CNCHPhCH2OH) with Ru(DMSO)4Cl2 in 2-propanol, is active for asymmetric transfer hydrogenation with best enantioselectivity up to 81%. A ruthenium complex of formula RuL2Cl2 is prepared and its crystal structure revealed that the two chiral P,N,O Schiff ligands are in meridional configuration. This complex is also an active catalyst for asymmetric transfer hydrogenation. However, the '[Ru(DMSO)4]Cl2 + chiral P,N,O ligand' protocol displays better enantioselectivity.
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