生物
瓦博格效应
糖酵解
基因
癌症
癌症研究
烯醇化酶
丙酮酸激酶
磷酸甘油酸激酶
甘油醛3-磷酸脱氢酶
乳酸脱氢酶A
癌细胞
基因表达
遗传学
酶
生物化学
免疫学
免疫组织化学
作者
Brigitte Altenberg,Karl Otto Greulich
出处
期刊:Genomics
[Elsevier]
日期:2004-12-01
卷期号:84 (6): 1014-1020
被引量:577
标识
DOI:10.1016/j.ygeno.2004.08.010
摘要
Using NIH's public database dbEST for expression of genes and ESTs, genes of the glycolysis pathway have been found to be overexpressed in a set of 24 cancers representing more than 70% of human cancer cases worldwide. Genes can be classified as those that are almost ubiquitously overexpressed, particularly glyceraldehyde-3-phosphate dehydrogenase, enolase 1, and also pyruvate kinase, and those that are overexpressed in less than 50% of the investigated cancers. Cancers can be classified as those with overexpression of the majority of the glycolysis genes, particularly lymph node, prostate, and brain cancer, in which essentially all glycolysis genes are overexpressed, and those with only sporadic overexpression, particularly cancers of the cartilage or bone marrow. This classification may be useful when cancer therapies aimed at the Warburg effect are designed.
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