Infections with Aspergillus Species

Invasive aspergillosis is a common infection in patients who are immunocompromised. The diagnosis of invasive aspergillosis is difficult in the absence of confirmation by tissue biopsy and histological studies. Therefore, recent advances that may be important for the development of highly sensitive and specific serodiagnostic tests for the early diagnosis of invasive aspergillosis are reviewed. The inability of the detection of antibody to Aspergillus to lead to early diagnosis of invasive aspergillosis also is emphasized. However, sensitive methods that reliably detect significant amounts of aspergillus antigen in body fluids of high-risk patients are currently being evaluated and may provide a noninvasive early diagnostic test that is both sensitive and specific. Also, current antifungal agents with anti-aspergillus activity that have potential as therapeutic or prophylactic agents are reviewed briefly.