Excretion of Thiamine in Diabetes: Unrelated to Glycosuria and Polyuria

Because of the similarity of diabetic peripheral neuropathy to the neuropathy seen in thiamine deficiency, the urinary excretion of thiamine in diabetes has received much attention. Several studies have been performed, but the renal excretion of thiamine in diabetes is still insufficiently known. The reasons for the reported differences are not obvious. However, the relationship between glycosuria and polyuria on one hand and thiamine excretion on the other has received only minor attention. The present study was undertaken in an attempt to investigate the influence of glycosuria and polyuria upon the excretion of thiamine.