Expression and Significance of Macrophage Migration Inhibitory Factor in the Retina of Diabetic Rats

Objective To detect the expression of macrophage migration inhibitory factor (MIF) in the retina of diabetic rats,and to investigate its role in the pathogenesis of diabetic retinopathy(DR).Methods Diabetic rats model was set by intraperitoneal injection of streptozocin (STZ),and the normal control group was set too,n=20.After 8 weeks,the different content of MIF in retina of the two groups were detected by ELISA.HE staining and immunohistochemical staining were used to observe the different depression of MIF in retina.Results Compared with the normal control group,blood glucose levels increased,the expression of MIF in retina increased significantly in the diabetic group.The difference was statistically significant(all P0.01).Conclusion The expression of MIF in retina of diabetic rats increased,related to the retinal inflammatory change may participate in early diabetic retinopathy.