Objective To assess health risk of heavy metals in drinking water in Jiangsu Province.Methods Six heavy metals concentration were detected by ICP-MS analysis method.Health risk associated 6 heavy metals in drinking water were assessed using USEPA health risk assessment model.Results The median concentration of six metals was:2 μg/L for Cr6+,0.5 μg/L for As,0.03 μg/L for Cd,0.36 μg/L for Pb,0.35 μg/L for Hg,5 μg/L for Zn.The carcinogenic risk level is:Cr6+ for 4.23×10-5/a,As for 5.66×10-6/a,Cd for 37.65×10-8/a.The non carcinogenic risk level is:Pb for 34.59×10-11/a,Hg for 16.35×10-10/a,Zn for 62.73×10-7/a.The rank of health risk is Cr6+ZnCdHgPb.The total health risk level is 5.47×10-5/a.Conclusion The total health risk level was higher than ICRP recommended level(5×10-5),while lower than US EPA recommended level(1×10-4).