Objective To study the clinical features of Klebsiella pneumoniae pneumonia in children and the resistance of Klebsiella pneumoniae which produced ESBLs.Methods The clinical features and the results of drug sensitivity test of 49 pediatrics diagnosed Klebsiella pneumoniae pneumonia were analyzed.Result The children especially those younger than one year were susceptible to Klebsiella pneumoniae pneumonia.Fever,cough,expectoration and anhelation were the main clinical manifestations which are atypical as well as the X-ray.Klebsiella pneumoniae with ESBLs(-)(34 cases) were sensitive to many antibiotics.Klebsiella pneumoniae with ESBLs(+)(15 cases) were cross-resistance to many antibiotics but sensitive to cephalosporin with activity and carbon vingl cephalosporin.Conclusion The clinical manifestations of Klebsiella pneumoniae pneumonia in children are atypical.It's more common in immunocompromised children 0-1 year old and rapidly progressed.To diagnose the disease need the pathogen detection,clinical manifestations and X-ray examination.The determination of reasonable treatment choice should be based on antibiotic susceptibility.