The relationship between hepatocyte apoptosis and liver microcirculation disturbance

Objective To study the relationship between hepatocyte apoptosis and liver microcirculation disturbance.Method Hepatocyte apoptosis was detected by TUNEL method.Ultrastructure of hepatocyte and the changes of sinus hepaticus microcirculation construction were observed by transmission electron microscope(TEM).Result The rate of hepatocyte apoptosis of patients with chronic hepatitis B increased obviously;hepatocyte cytolemma shrinked and divided to many apoptosis bodies.Decreased sizes and reduced numbers of sinusoidal endothelial cells′(SECs) fenestrae and collagen deposited in Disse space;basal lamina can be found on SECs and WP bodies were found in SECs.Conclusion Hepatocyte apoptosis is an important promoting factor to liver microcirculation disturbance in patients with chronic hepatitis B.