Objective:To study the clinical distribution and resistant characteristics of stenotrophomonas maltophilia in our hospital,and provide experimental evidence for controlling infections of stenotrophomonas maltophilia.Methods:Retrospective study all stenotrophomonas maltophilia separated from clinical samples from January 2007 to December 2007 in our hospital,weed out duplicate strains,and make drugsensitive test by K-B agar diffusion method.Results:There are 136 stenotrophomonas maltophilia strains separated from hemolymph(48.9%),121 stenotrophomonas maltophilia strains separated from sputamentum(43.5%) and 9 stenotrophomonas maltophilia strains separated from drainage(3.2%) among 278 stains,they are mainly distributed in liver ward,intensive care unit,respiration department and hematological ward,even maybe exist clone popularity of patients at liver ward(including some patients of liver-transplanted).The drug resistance rate of stenotrophomonas maltophilia to Minocycline is 95.9%,to Levofloxacin is 91.4%,to Sulfamethoprim is 89.4%,to Imipenem is 0%,to Ticarcillin-clavulnic Acid is only 37.6%.Conclusion:Stenotrophomonas maltophilia mainly effect bacteriemia and pulmonary infection in our hospital,and show multidrug resistance,the clinic should paid attention to it.