Objective To assess the effectiveness of percutaneous kyphoplasty(PKP)in the treatment of osteoporotic vertebral compression fracture(OVCF)with an intravertebral cleft. Methods PKP was performed in 27 OVCF patients with a cleft sign.The visual analogue scale(VAS)and Oswesty disability index(ODI)were used to score pain and measure ODI before and 24 hafter surgery.The anterioposterior and lateral film-the affected vertebra being made to be the central point-was taken to measure the height of anterior edge of injured vertebra and the Cobb angle of the injured vertebra. Results The surgeries in all the 27 patients were completed smoothly.Cement leakage was noted in 11 patients,with no any symptoms of nervous system were observed.Postoperatively,the VAS,ODI,and the Cobb angle of the injured vertebra decreased,the height of the anterior edge of injured vertebra increased,as compared with before surgery,the differences were significant(t=11.730-50.433,P0.01).Conclusion Percutaneous kyphoplasty is an effective surgical procedure in the treatment of osteoporotic vertebral compression fractures with an intravertebral cleft.