Studies of the Therapy of Melatonin on Rat Brain Cortex Oxidated Trauma after Following Traumatic Brain Injury

Objective To study the therapy of melatonin on rat brain cortex oxidated trauma after following traumatic brain injury and the relation of quantity and effect. Methods Seventy-two Sprague-Dawley rats were put into experiment and divided into six groups of 12 rats each.Traumatic brain injury has been developed through Feeney's method.MT and VC was given intraperitoneal(i.p.) after being injuried 5 minutes and determined the activities of GSH-Px and CAT and the content of MDA in rat brain cortex after 2 hours following TBI.The ultrastructure in brain cortex was also been examined. Results The activeties of of GSH-Px and CAT reduced in rat brain cortex following traumatic brain injury,but content of MDA rose.MT early treatment can partly reverse thses changes,and the more much MT was used,the more obviously effect on reducing the brain edema can be observed. Conclusions Melatonin was found to resist brain cortex oxidated trauma and be neuroprotective in instances of traumatic brain injury,its probable mechanism is related to protect the activities of GSH-Px and CAT.Thus,melatonin may be a valuable therapeutic agent in the treatment of TBI.