Resveratrol Increases CHD4 Gene Expression and Regulates Wnt Signaling in Chronic Myeloid Leukemia

Chronic myelogenous leukemia (CML) is a hematological disease resulting from generation of BCR/ABL oncogene. Resveratrol is an important phytoalexin which is contained in many plants and it has cytotoxic effects in various cancer types. Gene promoter methylation causes loss of tumor suppressor gene function in human cancer. CHD4 (Chromodomain/Helicase/DNA- binding domain) gene which contains a CpG island is a member of the cadherin family.