Radical-promoted cyclization of 3-allyl-2-arylquinazolinones mediated by silver( i ) salts to access SCF 3 /SCN-enriched dihydroisoquinolino[1,2- b ]quinazolinones

Herein, we describe an efficient approach for the synthesis of SCF₃- and SCN-functionalized polycyclic dihydroisoquinolino[1,2-b]quinazolinones through radical-mediated thio-functionalization of allylic alkenes followed by intramolecular cyclization. The transformation proceeds through sulfur-radical-triggered C-S and C-C bond formation, providing an efficient route to sulfur- and fluorine-enriched polycyclic quinazolinones. Moreover, this strategy offers high atom economy, operational simplicity, and broad substrate compatibility.