Visible Light Catalysis Promoted the Synthesis of Tetra‐C‐Substituted Pyrroles under External‐Oxidant‐Free Conditions

Abstract Pyrrole is recognized as a critical component in various natural molecules and bioactive products, making it a focal point in organic synthesis. In this study, we report a novel photoredox strategy that leverages visible light to catalyze the synthesis of tetra‐C‐substituted pyrrole derivatives from enamines, employing acridine and a cobaloxime as catalysts. This method offers significant advantages, including the elimination of external oxidants and the capability to conduct reactions under mild conditions, thereby expanding the range of viable pyrrole derivatives while maintaining functional group compatibility. Mechanism investigations demonstrated that radical species were involved in the process and light irradiation was essential for the efficient transformation.