Advancements in Enteric-coated Microspheres Formulation Development and Mangiferin Drug Delivery for the Treatment of Ulcerative Colitis

Introduction: Ulcerative colitis, an inflammatory disease of the colon, is prone to recurrence. Research into novel therapies for this condition is urgently required. The current investigation aims to ascertain the protective impact of microspheres loaded with mangiferin in acetic acidinduced ulcerative colitis (UC). Methods: The formulation significantly reduced inflammatory alterations, ulcer activity scores, and oxidative stress. Colitis was induced by injecting 1 mL of a 4% acetic acid solution. In addition to a macroscopical and gross evaluation, colon samples were tested for catalase and glutathione (GSH) activity. Results: Microspheres loaded with mangiferin reduced the severity of ulcerative colitis caused by acetic acid, as indicated by improvements in weight loss, macroscopic score, ulcer area, and histological score. Discussion: The anti-inflammatory effects of the microspheres may explain their ability to alleviate symptoms of acetic acid-induced ulcerative colitis. Conclusion: These findings suggest that enteric-coated microspheres loaded with mangiferin exhibit a protective effect against colon ulcers in rats and offer delayed-release properties compared to plain mangiferin.