Plasma metabolomics uncovers key metabolites and enhances prediction of aortic stenosis: insights from prospective cohort and Mendelian randomisation studies

Our study identified 39 metabolites with causal associations with AS risk, particularly apolipoprotein B-containing lipoproteins. The derived 12-metabolite panel significantly improved AS risk prediction, demonstrating the potential of NMR-based metabolomics to enhance AS risk stratification and targeted prevention.