粘合连接
神经发生
细胞生物学
ESCRT公司
化学
神经科学
生物
钙粘蛋白
生物化学
内体
细胞内
细胞
作者
Danping Lu,Yiqiang Zhi,Hui-Zhen Su,Xiaoyan Lin,Jingjing Lin,Yan Shi,Wenxiang Yi,Hong Cheng,Tongtong Zhang,Zhifei Fu,Liyu Chen,Zhi‐Qi Zhao,Huafu Chen,Zhiheng Xu,Wan‐Jin Chen,Ning Wang,Dan Xu
出处
期刊:Cell Reports
[Elsevier]
日期:2024-03-01
卷期号:43 (3): 113818-113818
标识
DOI:10.1016/j.celrep.2024.113818
摘要
Summary
Intricate cerebral cortex formation is orchestrated by the precise behavior and division dynamics of radial glial cells (RGCs). Endocytosis functions in the recycling and remodeling of adherens junctions (AJs) in response to changes in RGC activity and function. Here, we show that conditional disruption of ubiquitin-associated protein 1 (UBAP1), a component of endosomal sorting complex required for transport (ESCRT), causes severe brain dysplasia and prenatal ventriculomegaly. UBAP1 depletion disrupts the AJs and polarity of RGCs, leading to failure of apically directed interkinetic nuclear migration. Accordingly, UBAP1 knockout or knockdown results in reduced proliferation and precocious differentiation of neural progenitor cells. Mechanistically, UBAP1 regulates the expression and surface localization of cell adhesion molecules, and β-catenin over-expression significantly rescues the phenotypes of Ubap1 knockdown in vivo. Our study reveals a critical physiological role of the ESCRT machinery in cortical neurogenesis by regulating AJs of RGCs.
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