毛茛科
阿扑啡
癌细胞系
生物碱
化学
生药学
植物根系
细胞培养
立体化学
植物
生物
癌细胞
生物活性
癌症
体外
生物化学
遗传学
作者
Z Chen,Hangao Yang,Weining Zhu,Chunmei Xue,Hongmei Zhang,Yen-Ping Peng,Dahong Li,Hui‐Ming Hua
标识
DOI:10.1080/10286020.2024.2317826
摘要
Two new aporphine alkaloids, 6aR-2'-(3-oxobutenyl)-thaliadin (1) and N-methylthalisopynine (2), along with ten known analogs (3-12), were isolated from the roots of Thalictrum omeiense W. T. Wang et S. H. Wang. Their structures were determined by extensive spectroscopic and X-ray crystallographic analyses. Compounds 1-7 and 9-12 were tested for their antiproliferative effects in vitro against two human cancer cell lines (A549 and MCF-7). Among them, compounds 1, 3, and 7 exhibited moderate inhibitory activity against the tested cell lines with IC50 values ranging from 23.73 to 34.97 μM.
科研通智能强力驱动
Strongly Powered by AbleSci AI