对映选择合成
立体中心
催化作用
表面改性
过渡金属
杂原子
组合化学
有机催化
化学
碳纤维
有机化学
材料科学
戒指(化学)
复合数
物理化学
复合材料
作者
Xuemeng Chen,Steven L. Kramer
出处
期刊:Chem catalysis
[Elsevier]
日期:2024-01-01
卷期号:4 (1): 100854-100854
标识
DOI:10.1016/j.checat.2023.100854
摘要
Enantioselective C(sp3)−H functionalization is a highly efficient strategy for the introduction of new stereocenters and the synthesis of enantioenriched chiral compounds. Recent developments in the field of photoinduced transition-metal catalysis have led to impressive advances toward this goal. New methods involving photocatalyzed conversion of C(sp3)−H bonds into radical intermediates that are directly trapped by chiral transition-metal catalysts have proven particularly powerful. This perspective provides an overview of these methods for the direct transformation of non-acidic C(sp3)−H bonds into carbon–carbon or carbon–heteroatom bonds in an enantioselective fashion. We conclude with an outlook on challenges and future opportunities.
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