内科学
内分泌学
甘油三酯
脂肪因子
重性抑郁障碍
哈姆德
医学
萧条(经济学)
肥胖
脂肪组织
胆固醇
瘦素
扁桃形结构
显著性差异
经济
宏观经济学
作者
Qian Chen,Tao Sun,Qing He,Jing Yu,Xuechao Zhang,Lu Han,Yanping Ren
标识
DOI:10.1016/j.jpsychires.2024.01.046
摘要
The adipokines secreted by adipocytes might play an important role through crossing the blood brain barrier to the brain, which could mediate the common physiological pathway between depression and obesity. CTRP4, a member of the CTRP family, is highly expressed in human adipose tissue and brain tissue. this study aimed to measure serum C1q/TNF-related protein 4 (CTRP4) levels in depressive patients to explore the association between CTRP4 levels and depression. depressive patients (n = 138), healthy controls (n = 100) were enrolled from September 2020 to December 2021. The level of serum CTRP4 was measured by enzymes linked to immunosorbent assay (ELISA). Other biochemical indicators were measured by Advia 2400 automatic biochemistry analyzer. Depressive symptoms of patients were assessed using the Hamilton Depression Scale-24 item (HAMD-24). this study found that serum CTRP4 levels in the MDD group were lower than that of the health control (P < 0.001). Serum CTRP4 levels were negatively correlated with HAMD-24 scores (r = −0.368; P = 0.001). The serum CTRP4 levels were negatively correlated with Total Cholesterol (TC), Triglyceride (TG) and Low-Density Lipoprotein Cholesterol (LDL-C), but were positively associated with high density lipid-cholesterol (HDL-C) (r = −0.267, r = −0.255, r = −0.312 and r = 0.280; P = 0.017, P = 0.023, P = 0.005 and P = 0.012). The ROC curve of CTRP4 showed that the Area Under Curve (AUC) was 0.856, P < 0.001. the serum CTRP4 levels in MDD patients were lower than that in health control, which might mediate the physiological progress of MDD patients.
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