蜡螟
泊沙康唑
伊曲康唑
伏立康唑
着色芽生菌病
特比萘芬
微生物学
毒力
生物
两性霉素B
真菌
体内
抗真菌
基因
生物化学
植物
生物技术
作者
Dongmei Shi,Zhiya Yang,Wanqing Liao,Chen Liu,Liang Zhao,Huilin Su,Xiaodong Wang,Huan Mei,Min Chen,Yinggai Song,Sybren de Hoog,Shuwen Deng
出处
期刊:IMA fungus
[Springer Nature]
日期:2024-03-08
卷期号:15 (1)
标识
DOI:10.1186/s43008-023-00134-5
摘要
Chromoblastomycosis is the World Health Organization (WHO)-recognized fungal implantation disease that eventually leads to severe mutilation. Cladophialophora carrionii (C. carrionii) is one of the agents. However, the pathogenesis of C. carrionii is not fully investigated yet.We investigated the pathogenic potential of the fungus in a Galleria mellonella (G. mellonella) larvae infection model. Six strains of C. carrionii, and three of its environmental relative C. yegresii were tested. The G. mellonella model was also applied to determine antifungal efficacy of amphotericin B, itraconazole, voriconazole, posaconazole, and terbinafine.All strains were able to infect the larvae, but virulence potentials were strain-specific and showed no correlation with clinical background of the respective isolate. Survival of larvae also varied with infection dose, and with growth speed and melanization of the fungus. Posaconazole and voriconazole exhibited best activity against Cladophialophora, followed by itraconazole and terbinafine, while limited efficacy was seen for amphotericin B.Infection behavior deviates significantly between strains. In vitro antifungal susceptibility of tested strains only partly explained the limited treatment efficacy in vivo.
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