芳基
卤化物
光催化
组分(热力学)
催化作用
联轴节(管道)
化学
光化学
材料科学
有机化学
物理
光催化
烷基
热力学
冶金
作者
Mark C. Maust,Simon B. Blakey
标识
DOI:10.1021/acscatal.3c05988
摘要
Modern organic synthesis requires methodologies that bring together abundant feedstock chemicals in a mild and efficient manner. To aid in this effort, we have developed a multicomponent radical hydroxyarylation reaction that utilizes aryl halides, olefins, and O2 as the reaction components. Crucial to this advance was an oxidative, rather than a reductive, approach to aryl radical generation, which enables reaction tolerance to O2. This methodology displays a broad functional group tolerance with a variety of functionalized aryl halides and a broad array of olefins. Development of this methodology enables rapid access to biologically relevant hydroxyaryl products from simple, commercially available starting materials.
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