二甲双胍
氧化应激
链脲佐菌素
丙二醛
谷胱甘肽
糖尿病
内科学
抗氧化剂
医学
内分泌学
脂肪肝
化学
药理学
生物化学
酶
疾病
作者
Mahshid Ghanbari,Mohammad Shokrzadeh Lamuki,Forouzan Sadeghimahalli,Emran Habibi,Mohammad Reza Sayedi Moqadam
出处
期刊:Endocrine Regulations
[De Gruyter]
日期:2023-01-01
卷期号:57 (1): 242-251
标识
DOI:10.2478/enr-2023-0027
摘要
Abstract Objective. The aim of this study was the investigation of a treatment role of Artemisia annua L. (AA) on liver dysfunction and oxidative stress in high-fat diet/streptozotocin-induced diabetic (HFD/STZ) mice. Methods. Sixty mice were divided into 12 groups including control, untreated diabetic, and treated diabetic ones with metformin (250 mg/kg), and doses of 100, 200, and 400 mg/kg of water (hot and cold) and alcoholic (methanol) extracts of AA. Type 2 diabetes mellitus (T2DM) was induced in mice by high-fat diet for 8 weeks and STZ injection in experimental animals. After treatment with doses of 100, 200 or 400 mg/kg of AA extracts in HFD/STZ diabetic mice for 4 weeks, oxidative stress markers such as malondialdehyde (MDA), glutathione (GSH), and free radicals (ROS) were determined in the liver tissue in all groups. Results. Diabetic mice treated with metformin and AA extracts showed a significant decrease in ROS and MDA concentrations and a notable increase in GSH level in the liver. Effectiveness of higher doses of AA extracts (200 and 400 mg/kg), especially in hot-water and alcoholic ones, were similar to and/or even more effective than metformin. Conclusion. Therapeutic effects of AA on liver dysfunction showed that antioxidant activity of hot-water and alcoholic AA extracts were similar or higher than of metformin.
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