骨关节炎
软骨
关节软骨
生物信息学
自噬
疾病
炎症
医学
软骨下骨
生物
神经科学
病理
内科学
解剖
替代医学
遗传学
细胞凋亡
作者
Anke J. Roelofs,Cosimo De Bari
标识
DOI:10.1016/j.joca.2023.11.002
摘要
summary
Great progress continues to be made in our understanding of the multiple facets of osteoarthritis (OA) biology. Here, we review the major advances in this field and progress towards therapy development over the past year, highlighting a selection of relevant published literature from a PubMed search covering the year from the end of April 2022 to the end of April 2023. The selected articles have been arranged in themes. These include 1) molecular regulation of articular cartilage and implications for OA, 2) mechanisms of subchondral bone remodelling, 3) role of synovium and inflammation, 4) role of age-related changes including cartilage matrix stiffening, cellular senescence, mitochondrial dysfunction, metabolic dysfunction, and impaired autophagy, and 5) peripheral mechanisms of OA pain. Progress in the understanding of the cellular and molecular mechanisms responsible for the multiple aspects of OA biology is unravelling novel therapeutic targets for disease modification.
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