小胶质细胞
电针
吞噬作用
树突棘
脂多糖
再灌注损伤
医学
缺血
化学
药理学
神经科学
内科学
免疫学
生物
炎症
病理
针灸科
海马结构
替代医学
作者
Fan Zhang,Qian-yi Wang,Jie Zhou,Xiang Zhou,Wei Xia,Ling Hu,Hongliang Cheng,Qing Yu,Rong Cai
出处
期刊:iScience
[Elsevier]
日期:2023-09-01
卷期号:26 (9): 107645-107645
标识
DOI:10.1016/j.isci.2023.107645
摘要
A major side effect of reperfusion therapy following myocardial infarction is myocardial ischemia-reperfusion injury (MIRI). Electroacupuncture preconditioning (EA-pre) has a long history in the treatment of cardiovascular diseases. Here, we demonstrate how EA-pre attenuates MIRI by affecting the phagocytosis of neuronal dendritic spines of microglia of the fastigial nucleus (FNmicroglia). We observed that EA-pre increased activity in FNGABA and then improved myocardial injury by inhibiting abnormal activities of glutaminergic neurons of the FN (FNGlu) during MIRI. Interestingly, we observed changes in the quantity and shape of FN microglia in mice treated with EA-pre and a decrease in the phagocytosis of FNGABA neuronal dendritic spines by microglia. Furthermore, the effects of improving MIRI were reversed when EA-pre mice were chemically activated by intra-FN lipopolysaccharide injection. Overall, our results provide new insight indicating that EA-pre regulates microglial engulfment capacity, thus promoting the improvement of cardiac sympathetic nervous disorder during MIRI.
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