特应性皮炎
医学
杜皮鲁玛
疾病
免疫失调
发病机制
免疫学
重症监护医学
免疫系统
病理
作者
Gérard Milano,Stefano Forestieri,Micol Tedeschi,Amelia Licari,Valeria Brazzelli,Gian Luigi Marseglia
出处
期刊:Current Pediatric Reviews
[Bentham Science]
日期:2023-09-12
卷期号:20
标识
DOI:10.2174/1573396320666230912103136
摘要
Atopic dermatitis (AD) is the most frequent chronic-recurrent inflammatory skin disease in the pediatric age. It has a complex and multifactorial pathogenesis: the two key actors are impaired skin barrier function and immune system dysregulation, which represent the main targets of AD therapy. Monoclonal antibodies have revolutionized the management of moderate-to-severe AD, by selective inhibition of key cytokines in the pathogenetic process. For this reason, there is great interest in exploring AD pathogenetic mechanisms to develop new therapeutic strategies. This review aims to summarize the most recent scientific evidence on available and future biological therapies for the treatment of pediatric AD, emphasizing the molecular mechanisms underlying their action.
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