HLA-B27, axial spondyloarthritis and survival

医学 人口 强直性脊柱炎 队列 生命银行 内科学 危险系数 预期寿命 队列研究 骶髂关节炎 人口学 置信区间 环境卫生 遗传学 生物 社会学
作者
Zhixiu Li,M. K. Khan,Sjef M. van der Linden,Björn Winkens,Peter M. Villiger,Heinz Baumberger,Hermine van Zandwijk,Muhammad Asim Khan,Matthew A. Brown
出处
期刊:Annals of the Rheumatic Diseases [BMJ]
卷期号:82 (12): 1558-1567 被引量:3
标识
DOI:10.1136/ard-2023-224434
摘要

Ankylosing spondylitis (AS), and carriage of HLA-B27 gene in otherwise healthy individuals, are reportedly associated with increased mortality. We evaluated this hypothesis, using data from both a 35-year AS follow-up study and UK Biobank data.In 1985, 363 members of the Swiss AS Patient Society and 806 relatives were screened clinically and then radiographically for AS/axial spondyloarthritis (axSpA). Life expectancy was analysed in 377 axSpA patients having available pelvic radiographs and HLA-B27 status, comparing with matched Swiss population data. Survival in relation to HLA-B27 status in the general population was studied in UK Biobank European-ancestry participants (n=407 480, n=30 419 deaths).AS patients have increased standardised mortality rate (SMR) compared with the general population (1.37, 95% CI 1.11 to 1.62). This increase was significant for HLA-B27-positive AS (SMR 1.38, 95% CI 1.11 to 1.65). Shortened life expectancy was observed among both HLA-B27-positive AS women (SMR 1.77, 95% CI 1.09 to 2.70) and men (SMR 1.31, 95% CI 1.02 to 1.59). Patients with non-radiographic axSpA (nr-axSpA) had significantly lower SMR: 0.44 (95% CI 0.23 to 0.77), compared with the general population. In the UK Biobank European-ancestry population cohort, HLA-B27 carriage was not significantly associated with any change in mortality (HR 1, 95% CI 0.97 to 1.1, p=0.349, adjusted by sex), in either males (HR 1, 95% CI 0.98 to 1.1, p=0.281) or females (HR 0.96, 95% CI 0.9 to 1, p=0.232), and no increase in vascular disease mortality was observed.AS patients, but not nr-axSpA patients, have a significantly shortened life expectancy. Increased mortality is particularly significant among women with HLA-B27-positive AS. HLA-B27 carriage in the European-ancestry general population does not influence survival, or the risk of death due to vascular disease.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2秒前
千帆完成签到,获得积分10
2秒前
千帆发布了新的文献求助10
3秒前
亭语完成签到 ,获得积分0
6秒前
果果完成签到,获得积分10
6秒前
lv完成签到,获得积分10
8秒前
batmanrobin完成签到,获得积分10
10秒前
清逸之风发布了新的文献求助30
11秒前
11秒前
12秒前
满意的小猫完成签到,获得积分10
14秒前
科目三应助健壮听筠采纳,获得10
15秒前
keke发布了新的文献求助10
17秒前
楚襄谷完成签到 ,获得积分10
19秒前
研友_Lj7Rxn发布了新的文献求助10
20秒前
刮风这天完成签到,获得积分10
20秒前
星辰大海应助大鹏采纳,获得10
20秒前
22秒前
24秒前
搜集达人应助zzpj采纳,获得10
24秒前
yjjslbyfbgfwz发布了新的文献求助10
26秒前
sjsuA完成签到,获得积分10
28秒前
28秒前
gjww应助ramsdale采纳,获得10
32秒前
乘一完成签到,获得积分10
34秒前
78Erii发布了新的文献求助30
35秒前
放羊的小陌完成签到,获得积分10
35秒前
李健的粉丝团团长应助zzpj采纳,获得10
37秒前
梁子奥里给完成签到,获得积分10
37秒前
38秒前
39秒前
MasterE完成签到,获得积分10
39秒前
40秒前
TKMY发布了新的文献求助10
44秒前
香蕉孤云发布了新的文献求助10
44秒前
现代的烤鸡完成签到,获得积分10
46秒前
桐桐应助yjjslbyfbgfwz采纳,获得10
48秒前
已经让完成签到 ,获得积分10
51秒前
香蕉孤云完成签到,获得积分10
53秒前
光子完成签到,获得积分10
55秒前
高分求助中
请在求助之前详细阅读求助说明 20000
One Man Talking: Selected Essays of Shao Xunmei, 1929–1939 1000
Yuwu Song, Biographical Dictionary of the People's Republic of China 700
[Lambert-Eaton syndrome without calcium channel autoantibodies] 520
The Three Stars Each: The Astrolabes and Related Texts 500
Sphäroguß als Werkstoff für Behälter zur Beförderung, Zwischen- und Endlagerung radioaktiver Stoffe - Untersuchung zu alternativen Eignungsnachweisen: Zusammenfassender Abschlußbericht 500
Additive Manufacturing Design and Applications 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 有机化学 工程类 生物化学 纳米技术 物理 内科学 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 电极 光电子学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 2464830
求助须知:如何正确求助?哪些是违规求助? 2133256
关于积分的说明 5435544
捐赠科研通 1859140
什么是DOI,文献DOI怎么找? 924652
版权声明 562561
科研通“疑难数据库(出版商)”最低求助积分说明 494693