热卡限制
卡路里
长寿
肥胖
疾病
老年学
低热量饮食
糖尿病
医学
低热量饮食
生物
环境卫生
生理学
减肥
内分泌学
内科学
作者
Maria M. Mihaylova,Amandine Chaix,Mirela Delibegović,Jon J. Ramsey,Joseph Bass,Girish C. Melkani,Rajat Singh,Jake Y. Chen,William W. Ja,Mimi Shirasu-Hiza,Mary N. Latimer,Julie A. Mattison,Anna Thalacker‐Mercer,Vishwa Deep Dixit,Satchidananda Panda,Dudley W. Lamming
出处
期刊:Cell Metabolism
[Elsevier]
日期:2023-07-01
卷期号:35 (7): 1114-1131
被引量:15
标识
DOI:10.1016/j.cmet.2023.06.008
摘要
An epidemic of obesity has affected large portions of the world, increasing the risk of developing many different age-associated diseases, including cancer, cardiovascular disease, and diabetes. In contrast with the prevailing notion that "a calorie is just a calorie," there are clear differences, within and between individuals, in the metabolic response to different macronutrient sources. Recent findings challenge this oversimplification; calories from different macronutrient sources or consumed at different times of day have metabolic effects beyond their value as fuel. Here, we summarize discussions conducted at a recent NIH workshop that brought together experts in calorie restriction, macronutrient composition, and time-restricted feeding to discuss how dietary composition and feeding schedule impact whole-body metabolism, longevity, and healthspan. These discussions may provide insights into the long-sought molecular mechanisms engaged by calorie restriction to extend lifespan, lead to novel therapies, and potentially inform the development of a personalized food-as-medicine approach to healthy aging.
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