大麻
大麻
大麻素
大麻酚
生物
四氢大麻酚
毛状体
生物技术
植物
生物化学
精神科
医学
受体
作者
Ziyan Xie,Yaolei Mi,Lingzhe Kong,Ming Gao,Shanshan Chen,Weiqiang Chen,Xiangying Meng,Wei Sun,Shilin Chen,Zhichao Xu
摘要
Is Cannabis a boon or bane? Cannabis sativa has long been a versatile crop for fiber extraction (industrial hemp), traditional Chinese medicine (hemp seeds), and recreational drugs (marijuana). Cannabis faced global prohibition in the twentieth century because of the psychoactive properties of ∆9-tetrahydrocannabinol; however, recently, the perspective has changed with the recognition of additional therapeutic values, particularly the pharmacological potential of cannabidiol. A comprehensive understanding of the underlying mechanism of cannabinoid biosynthesis is necessary to cultivate and promote globally the medicinal application of Cannabis resources. Here, we comprehensively review the historical usage of Cannabis, biosynthesis of trichome-specific cannabinoids, regulatory network of trichome development, and synthetic biology of cannabinoids. This review provides valuable insights into the efficient biosynthesis and green production of cannabinoids, and the development and utilization of novel Cannabis varieties.
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