化学
试剂
钴
催化作用
反离子
芳基
卤化物
组合化学
反应性(心理学)
烷基
盐(化学)
锌
磺酰
有机化学
离子
医学
替代医学
病理
作者
Shou‐Cheng Dong,Zhenfeng Tian,J. Wang,Lin He,Jie Li
标识
DOI:10.1016/j.jcat.2023.06.037
摘要
Salt-stabilized organozinc pivalates display crucial counterion-effect by OPiv-coordination, which steer an efficient cobalt-catalyzed 1,4-carbosulfonylation of 1,3-enynes with sulfonyl chlorides under simple and mild reaction conditions. Notably, both aryl and alkyl zinc pivalates show superior reactivity compared to conventional halide-supported organozinc reagents, thus providing an expedient access to the preparation of highly functionalized α-allenyl sulfones via cascade C–C/C–S bond formation. Moreover, late-stage modifications of drug-like compounds and facile transformations of the resulting allenes illustrate the synthetic utility of this protocol.
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