FePSe3‐Nanosheets‐Integrated Cryogenic‐3D‐Printed Multifunctional Calcium Phosphate Scaffolds for Synergistic Therapy of Osteosarcoma

Abstract Clinical treatment of osteosarcoma encounters great challenges of postsurgical tumor recurrence and extensive bone defect. To develop an advanced artificial bone substitute that can achieve synergistic bone regeneration and tumor therapy for osteosarcoma treatment, a multifunctional calcium phosphate composite enabled by incorporation of bioactive FePSe 3 ‐nanosheets within the cryogenic‐3D‐printed α ‐tricalcium phosphate scaffold (TCP‐FePSe 3 ) is explored. The TCP‐FePSe 3 scaffold exhibits remarkable tumor ablation ability due to the excellent NIR‐II (1064 nm) photothermal property of FePSe 3 ‐nanosheets. Moreover, the biodegradable TCP‐FePSe 3 scaffold can release selenium element to suppress tumor recurrence by activating of the caspase‐dependent apoptosis pathway. In a subcutaneous tumor model, it is demonstrated that tumors can be efficiently eradicated via the combination treatment with local photothermal ablation and the antitumor effect of selenium element. Meanwhile, in a rat calvarial bone defect model, the superior angiogenesis and osteogenesis induced by TCP‐FePSe 3 scaffold have been observed in vivo. The TCP‐FePSe 3 scaffold possesses improved capability to promote the repair of bone defects via vascularized bone regeneration, which is induced by the bioactive ions of Fe, Ca, and P released during the biodegradation of the implanted scaffolds. The TCP‐FePSe 3 composite scaffolds fabricated by cryogenic‐3D‐printing illustrate a distinctive strategy to construct multifunctional platform for osteosarcoma treatment.