恶病质
浪费的
医学
骨骼肌
癌症
肌萎缩
分解代谢
炎症
癌症恶病质
生物信息学
蛋白质分解代谢
内科学
消瘦综合征
全身炎症
内分泌学
癌症研究
生物
新陈代谢
生物化学
氨基酸
作者
Tania Setiawan,Ita Novita Sari,Yoseph Toni Wijaya,Nadya Marcelina Julianto,Jibran Sualeh Muhammad,Hyeok Lee,Ji Heon Chae,Hyog Young Kwon
标识
DOI:10.1186/s13045-023-01454-0
摘要
Muscle wasting is a consequence of physiological changes or a pathology characterized by increased catabolic activity that leads to progressive loss of skeletal muscle mass and strength. Numerous diseases, including cancer, organ failure, infection, and aging-associated diseases, are associated with muscle wasting. Cancer cachexia is a multifactorial syndrome characterized by loss of skeletal muscle mass, with or without the loss of fat mass, resulting in functional impairment and reduced quality of life. It is caused by the upregulation of systemic inflammation and catabolic stimuli, leading to inhibition of protein synthesis and enhancement of muscle catabolism. Here, we summarize the complex molecular networks that regulate muscle mass and function. Moreover, we describe complex multi-organ roles in cancer cachexia. Although cachexia is one of the main causes of cancer-related deaths, there are still no approved drugs for cancer cachexia. Thus, we compiled recent ongoing pre-clinical and clinical trials and further discussed potential therapeutic approaches for cancer cachexia.
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