Real‐Time Intraoperative Detection of Margins for Oral Cavity Squamous Cell Carcinoma

Abstract Obtaining negative surgical cancer margins is the strongest predictor for the long‐term survival of oral cavity squamous cell carcinoma patients. To verify that the tumor has been completely removed, surgeons rely on pathologic evaluation of frozen sections to determine surgical margins, which can be time‐consuming and subjective. Herein, we detail the real‐time intraoperative use of dynamic optical contrast imaging (DOCI), a novel imaging modality that rapidly distinguishes head and neck cancer from healthy adjacent tissues based on fluorescence decay information from spectral bands in the UV‐VIS range. Analysis of DOCI revealed microscopic characterization sufficient for tissue type identification consistent with histology ( p < .05). DOCI delivers a clinically relevant tool that may better inform and drive precision surgery, directly impacting surgical outcomes and improving overall survival for our patients.