Deprotonation‐Constructed Instant Gelation Coating for Staphylococcus Disinfection and Preservation of Fresh Food in Multiple Scenarios

Abstract The ancient proverb “disease enters through the mouth” elucidates the connection between food and pathogens, underscoring the pivotal role of food preservation in preventing foodborne diseases. Drawing inspiration from ancient food preservation techniques such as waxing and the use of spices, a novel approach combining the deprotonation‐induced solid–liquid phase separation of natural polymer solutions with the solubilization of plant–derived antibacterial compounds has been developed. The “two‐step soaking” construction strategy enables the creation of biodegradable and adaptable for hydrogel coatings with micro‐scale thickness. These multifunctional coatings can be applied to the surfaces of fresh fruits, vegetables, and meats in 35 s, providing both moisture retention and antioxidant protection. The coating's versatility allows for the targeted can achieve the elimination of various Staphylococcus and other bacterial strains through the selection of bactericides with differing antibacterial mechanisms. The scalability of this approach offers significant potential for broad applications in sterilization and food preservation in across diverse contexts.