Targeting tsRNA-1797 Alleviates Diabetes-Induced Vascular Dysfunction Through Modulating Purine Metabolism

tsRNA-1797 is a key regulator of diabetes-induced retinal vascular dysfunction. Overexpression of tsRNA-1797 exacerbates retinal vascular dysfunction in diabetes. tsRNA-1797 disrupts purine metabolism in retinal vascular endothelial cells. tsRNA-1797 directly targets CD73, reducing adenosine production and causing retinal vascular dysfunction in diabetic retinopathy.