Interpretive consistency of a qualitative 68Ga-PSMA PET framework for treatment response assessment in hepatocellular carcinoma: a head-to-head comparison with cross-sectional imaging

A qualitative PSMA PET framework for HCC treatment response assessment yields nearly perfect interpretive consistency, outperforming CT/MRI-based criteria in post-ICI settings. These findings provide the foundation to validate PSMA-based response against oncologic outcomes in future clinical trials, a critical step toward guiding patient management and accelerating therapeutic innovation in HCC.