生物利用度
溶解
耐折性
渗透
材料科学
药品
剂型
复合数
溶解试验
曲美他嗪
起效
色谱法
生物医学工程
化学
药理学
医学
复合材料
首过效应
有机化学
生物制药分类系统
生物化学
膜
出处
期刊:FABAD journal of pharmaceutical sciences
[FABAD Farmasotik Bilimler Ankara Dernegi]
日期:2022-11-29
标识
DOI:10.55262/fabadeczacilik.1085351
摘要
A fast-dissolving dosage form is an approach used to improve therapeutic efficacy and bioavailability by avoiding the first-pass metabolism of the cargo. Besides, the approach causes rapid cargo absorption from the pre-gastric area which may outcome in the quick inception of action. The trimetazidine dihydrochloride (TDC) is an anti-anginal drug and there is a prerequisite to provide fast onset of action to treat angina. Therefore, the present work was aimed to prepare and evaluate fast-dissolving oral films (FDOF) of TDC to provide fast onset of action. The FDOF is prepared by using the solvent casting method and it was optimized by employing a central composite statistical design. The two independent variables such as HPMC K4M and PEG 400 are the film-forming polymers which are evaluated at three levels. The dependent variables selected as folding endurance, disintegration time, and % drug release. The formulation was prepared and optimized the batch F-4 showed the least disintegration time (19 s) and the highest drug release (98.55±7.90%). Moreover, the ex-vivo mucus permeation study showed better permeation and satisfying physicochemical properties. As per the above results, we conclude that the prepared formulation could be a novel dosage form to improve drug delivery and patient compliance.
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