彭布罗利珠单抗
无容量
医学
加药
肿瘤科
免疫检查点
免疫疗法
重症监护医学
癌症
内科学
作者
Ruben Malmberg,Michiel Zietse,Daphne W Dumoulin,Jeroen J M A Hendrikx,Joachim Aerts,Astrid A.M. van der Veldt,Birgit C. P. Koch,Stefan Sleijfer,Roelof W F van Leeuwen
出处
期刊:Lancet Oncology
[Elsevier]
日期:2022-12-01
卷期号:23 (12): e552-e561
被引量:12
标识
DOI:10.1016/s1470-2045(22)00554-x
摘要
Immune checkpoint inhibitors have revolutionised cancer treatment by offering durable responses to many patients with solid and haematological cancers. The high prices and increasing use of immune checkpoint inhibitors put considerable strain on health-care budgets globally. This financial strain could jeopardise patients' access to these anti-cancer therapies. However, substantial evidence suggests that immune checkpoint inhibitors are being administered at doses that exceed the minimum dose required for maximum anti-tumour efficacy. Therefore, investigating and implementing the most cost-effective dosing strategies for immune checkpoint inhibitors are urgently necessary. This Personal View provides an overview of existing data on immune checkpoint inhibitor pharmacology and (novel) dosing strategies for anti-PD-1 therapy with nivolumab and pembrolizumab, with a special focus on cost-effectiveness and saving potential. Furthermore, specific recommendations to guide health-care professionals are provided, through the process of prescribing, rounding, preparing, and administering nivolumab and pembrolizumab in the most practical and cost-effective way possible.
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