纤维小体
生物过程
合成生物学
生化工程
生物量(生态学)
纳米技术
化学
计算机科学
纤维素酶
纤维素
生物化学
材料科学
生物
计算生物学
化学工程
工程类
热室梭菌
农学
作者
Shen‐Long Tsai,Qing Sun,Wilfred Chen
标识
DOI:10.1016/j.copbio.2022.102840
摘要
The primary obstacle impeding the more widespread use of biomass for energy and chemical production is the absence of a low-cost technology for overcoming their recalcitrant nature. It has been shown that the overall cost can be reduced by using a 'consolidated' bioprocessing (CBP) approach, in which enzyme production, biomass hydrolysis, and sugar fermentation can be combined. Cellulosomes are enzyme complexes found in many anaerobic microorganisms that are highly efficient for biomass depolymerization. While initial efforts to display synthetic cellulosomes have been successful, the overall conversion is still low for practical use. This limitation has been partially alleviated by displaying more complex cellulsome structures either via adaptive assembly or by using synthetic consortia. Since synthetic cellulosome nanostructures have also been created using either protein nanoparticles or DNA as a scaffold, there is the potential to tether these nanostructures onto living cells in order to further enhance the overall efficiency.
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