Delineating the Heterogeneity of Alzheimer’s Disease and Mild Cognitive Impairment Using Normative Models of Dynamic Brain Functional Networks

Alzheimer's disease (AD), which has been identified as the most common type of dementia, presents considerable heterogeneity in its clinical manifestations. Early intervention at the stage of mild cognitive impairment (MCI) holds potential in AD prevention. However, characterizing the heterogeneity of neurobiological abnormalities and identifying MCI subtypes pose significant challenges.