上睑下垂
炎症体
机制(生物学)
效应器
细胞生物学
炎症
半胱氨酸蛋白酶1
化学
生物
免疫学
认识论
哲学
作者
Xianhui Li,Xiang Qiong,Chuanjun Fu
出处
期刊:Protein and Peptide Letters
[Bentham Science]
日期:2022-11-01
卷期号:29 (11): 911-916
标识
DOI:10.2174/0929866529666220829152631
摘要
In recent years, cell pyroptosis has made it widely concerned. Pyroptosis is characterized by the activation of pathways leading to the activation of NLRP3 inflammasome and its downstream effector, such as interleukin (IL)-1β and IL-18, which has close relationship with inflammation. Recent evidence supports that CoenzymeQ10 (CoQ10) reduces related inflammatory factors (NLRP3, IL-1β and IL-18), which are associated with cell pyroptosis. This paper reviews the possible mechanisms of CoQ10 inhibiting pyroptosis of different cells and its possible mechanism. Further research is needed to better define the response effects of CoQ10 on specific aspects of cell pyroptosis (such as priming, promotion, and signaling), and to further investigate the organizational and cellular mechanisms by which CoQ10 reduces pyroptosis in different cells.
科研通智能强力驱动
Strongly Powered by AbleSci AI