晶体管
电化学
计算机科学
连续血糖监测
纳米技术
材料科学
医学
化学
电气工程
电极
内科学
工程类
物理化学
电压
血糖性
胰岛素
作者
Jing Bai,Dingyao Liu,Xinyu Tian,Yan Wang,Binbin Cui,Yilin Yang,Shilei Dai,Wensheng Lin,Jixiang Zhu,Jinqiang Wang,Aimin Xu,Zhen Gu,Shiming Zhang
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2024-04-19
卷期号:10 (16)
标识
DOI:10.1126/sciadv.adl1856
摘要
Continuous glucose monitoring systems (CGMs) are critical toward closed-loop diabetes management. The field's progress urges next-generation CGMs with enhanced antinoise ability, reliability, and wearability. Here, we propose a coin-sized, fully integrated, and wearable CGM, achieved by holistically synergizing state-of-the-art interdisciplinary technologies of biosensors, minimally invasive tools, and hydrogels. The proposed CGM consists of three major parts: (i) an emerging biochemical signal amplifier, the organic electrochemical transistor (OECT), improving the signal-to-noise ratio (SNR) beyond traditional electrochemical sensors; (ii) a microneedle array to facilitate subcutaneous glucose sampling with minimized pain; and (iii) a soft hydrogel to stabilize the skin-device interface. Compared to conventional CGMs, the OECT-CGM offers a high antinoise ability, tunable sensitivity and resolution, and comfort wearability, enabling personalized glucose sensing for future precision diabetes health care. Last, we discuss how OECT technology can help push the limit of detection of current wearable electrochemical biosensors, especially when operating in complicated conditions.
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