增强子
生物
表观遗传学
癌变
后生
基因表达调控
计算生物学
基因表达
癌症
基因
遗传学
DNA甲基化
作者
Eros Di Giorgio,Roberta Benetti,Emanuela Kerschbamer,Luigi E. Xodo,Claudio Brancolini
标识
DOI:10.1016/bs.ircmb.2023.03.013
摘要
Super-enhancers evolve as elements at the top of the hierarchical control of gene expression. They are important end-gatherers of signaling pathways that control stemness, differentiation or adaptive responses. Many epigenetic regulations focus on these regions, and not surprisingly, during the process of tumorigenesis, various alterations can account for their dysfunction. Super-enhancers are emerging as key drivers of the aberrant gene expression landscape that sustain the aggressiveness of cancer cells. In this review, we will describe and discuss about the structure of super-enhancers, their epigenetic regulation, and the major changes affecting their functionality in cancer.
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