明胶
纳米纤维
伤口愈合
材料科学
自愈水凝胶
聚己内酯
伤口敷料
壳聚糖
细胞外基质
静电纺丝
生物医学工程
高分子化学
化学
纳米技术
复合材料
外科
聚合物
医学
生物化学
作者
Yu Fan,Atta ur Rehman Khan,Yaqiang Li,Binan Zhao,Xianrui Xie,Mohamed H. El‐Newehy,Hany El‐Hamshary,Yosry Morsi,Jun Li,Jianfeng Pan,Xiumei Mo
标识
DOI:10.1016/j.compositesb.2022.110294
摘要
Acute skin wounds often lead to tissue defects and bacterial infection, leading to the suffering of patients. In this study, we reported a multifunctional nanofiber reinforced photo-crosslinking hydrogel wound dressing mainly based on natural biomaterials to mimic the structure and components of the native extracellular matrix (ECM). Gelatin-methacryloyl (GelMA), Thioglycolic acid-modified chitosan (TCS) and 3-buten-1-amine (BA) modified polycaprolactone nanofiber (PCLPBA) were prepared and photo-crosslinked into GTP hydrogel. Among all hydrogels, the GTP4 hydrogel possessed rapid liquid-gel transition at ultraviolet (UV) exposure, excellent antibacterial effect, antioxidant property, and printability through 3D printing. Besides, NIH 3T3 cells proliferated well and invaded GTP4 hydrogel. When it was applied to the full-thickness skin defect, GTP4 hydrogel showed the enhanced angiogenesis, re-epithelialization and wound healing effect. Therefore, these findings indicate that the GTP4 hydrogel is a promising wound dressing for acute skin wounds.
科研通智能强力驱动
Strongly Powered by AbleSci AI