光热治疗
材料科学
纳米技术
体内
癌症研究
三阴性乳腺癌
癌症
乳腺癌
医学
内科学
生物
生物技术
作者
Jing Bao,Yingran Wang,Chenglong Li,Cheng Yang,Hanqing Xu,Qingle Liang,Yang Zhou,Ligai Zhang,Yuan He,Hao Tong,Haiming Wu,Dan Luo,Yi Yang,Ming Chen,Mingxuan Gao
标识
DOI:10.1016/j.mtnano.2022.100211
摘要
Copper chalcogenide nanocrystal is a promising photothermal transduction material for photoacoustic imaging and photothermal therapy. But how to ameliorate its photothermal conversion efficiency in a controllable manner is still not well understood. Here, a novel gold-promoting-satellite Cu2-xSe (GPS–CS) nanoparticle was developed by simple in situ reduction. Our simulated models indicated that maintaining the number of gold satellites at ∼10 satellites per Cu2-xSe can significantly boost photothermal conversion efficiency. The GPS-CS exhibited higher photothermal conversion efficiency and less toxicity than the bare Cu2-xSe, and the programmed death-1 (PD-1) modified GPS-CS (GPS–[email protected]) nanocomplex presented excellent targeting ability both in vitro and in vivo. We further treated this nanocomplex in TNBC-bearing mice with photothermal targeting therapy (PTTT). The tumor was significantly inhibited or totally ablated; meanwhile, the normocytic normochromic anemia and hepatic metastasis were ameliorated. This work provides an appealing modification strategy for boosting the photothermal conversion efficiency of Cu2-xSe for effective PTTT.
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