泛素连接酶
细胞毒性T细胞
CD8型
Treg细胞
生物
免疫学
癌症免疫疗法
癌症研究
作者
Dominik Wolf,Gottfried Baier
出处
期刊:Cancer immunology research
[American Association for Cancer Research]
日期:2022-04-01
卷期号:10 (4): 370-370
标识
DOI:10.1158/2326-6066.cir-22-0080
摘要
In this issue, Han and colleagues demonstrate in preclinical cancer models that genetic deletion of the E3 ubiquitin ligase Cbl proto-oncogene B (CBLB) in adoptively transferred CD8+ T cells induces resistance to regulatory T cells. CBLB deletion induces IFNγ and downmodulates TGFβ/SMAD signaling. This ultimately enforces these cells to be way more effective against various cancers. See related article by Han et al., p. 437 (4).
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