Silencing Gene‐Engineered Injectable Hydrogel Microsphere for Regulation of Extracellular Matrix Metabolism Balance (Small Methods 4/2022)

Rechargeable Batteries In article number 2101201, Wenguo Cui, Xiaodong Liu, and co-workers construct an injectable circRNA silencing-hydrogel microsphere, capable of targeting nutrient-restricted microenvironments to regulate the extracellular matrix metabolism balance by grafting circSTC2 silencing genes-loaded DOTAP/Chol/DOPE cationic liposomes on methacrylated hyaluronic acid microspheres via amide bonds, which can precisely control the release of gene vectors and effectively silence pathological genes in nucleus pulposus cells.